Choosing important health outcomes for comparative effectiveness research: An updated systematic review and involvement of low and middle income countries
Identifieur interne : 000439 ( Main/Exploration ); précédent : 000438; suivant : 000440Choosing important health outcomes for comparative effectiveness research: An updated systematic review and involvement of low and middle income countries
Auteurs : Katherine Davis [Royaume-Uni] ; Sarah L. Gorst [Royaume-Uni] ; Nicola Harman [Royaume-Uni] ; Valerie Smith [Irlande (pays)] ; Elizabeth Gargon [Royaume-Uni] ; Douglas G. Altman [Royaume-Uni] ; Jane M. Blazeby [Royaume-Uni] ; Mike Clarke [Royaume-Uni] ; Sean Tunis [États-Unis] ; Paula R. Williamson [Royaume-Uni]Source :
- PLoS ONE [ 1932-6203 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Clinical Trials as Topic (MeSH), Comparative Effectiveness Research (methods), Comparative Effectiveness Research (trends), Delphi Technique (MeSH), Developed Countries (MeSH), Developing Countries (MeSH), Humans (MeSH), Outcome Assessment, Health Care (methods), Outcome Assessment, Health Care (trends).
- MESH :
Abstract
Core outcome sets (COS) comprise a minimum set of outcomes that should be measured and reported in all trials for a specific health condition. The COMET (Core Outcome Measures in Effectiveness Trials) Initiative maintains an up to date, publicly accessible online database of published and ongoing COS. An annual systematic review update is an important part of this process.
This review employed the same, multifaceted approach that was used in the original review and the previous two updates. This approach has identified studies that sought to determine which outcomes/domains to measure in clinical trials of a specific condition. This update includes an analysis of the inclusion of participants from low and middle income countries (LMICs) as identified by the OECD, in these COS.
Eighteen publications, relating to 15 new studies describing the development of 15 COS, were eligible for inclusion in the review. Results show an increase in the use of mixed methods, including Delphi surveys. Clinical experts remain the most common stakeholder group involved. Overall, only 16% of the 259 COS studies published up to the end of 2016 have included participants from LMICs.
This review highlights opportunities for greater public participation in COS development and the involvement of stakeholders from a wider range of geographical settings, in particular LMICs.
Url:
DOI: 10.1371/journal.pone.0190695
PubMed: 29438429
PubMed Central: 5810981
Affiliations:
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Gorst</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Harman, Nicola" sort="Harman, Nicola" uniqKey="Harman N" first="Nicola" last="Harman">Nicola Harman</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Valerie" sort="Smith, Valerie" uniqKey="Smith V" first="Valerie" last="Smith">Valerie Smith</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland</addr-line></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Nursing and Midwifery, Trinity College Dublin, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Gargon, Elizabeth" sort="Gargon, Elizabeth" uniqKey="Gargon E" first="Elizabeth" last="Gargon">Elizabeth Gargon</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Altman, Douglas G" sort="Altman, Douglas G" uniqKey="Altman D" first="Douglas G." last="Altman">Douglas G. Altman</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Blazeby, Jane M" sort="Blazeby, Jane M" uniqKey="Blazeby J" first="Jane M." last="Blazeby">Jane M. Blazeby</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>MRC ConDuCT II Hub for Trials Methodology Research, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC ConDuCT II Hub for Trials Methodology Research, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Mike" sort="Clarke, Mike" uniqKey="Clarke M" first="Mike" last="Clarke">Mike Clarke</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Centre for Public Health, Queen’s University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Public Health, Queen’s University Belfast, Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Tunis, Sean" sort="Tunis, Sean" uniqKey="Tunis S" first="Sean" last="Tunis">Sean Tunis</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Center for Medical Technology Policy (CMTP), World Trade Center Baltimore, Baltimore, MD, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Medical Technology Policy (CMTP), World Trade Center Baltimore, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Williamson, Paula R" sort="Williamson, Paula R" uniqKey="Williamson P" first="Paula R." last="Williamson">Paula R. Williamson</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical Trials as Topic (MeSH)</term><term>Comparative Effectiveness Research (methods)</term><term>Comparative Effectiveness Research (trends)</term><term>Delphi Technique (MeSH)</term><term>Developed Countries (MeSH)</term><term>Developing Countries (MeSH)</term><term>Humans (MeSH)</term><term>Outcome Assessment, Health Care (methods)</term><term>Outcome Assessment, Health Care (trends)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Essais cliniques comme sujet (MeSH)</term><term>Humains (MeSH)</term><term>Méthode Delphi (MeSH)</term><term>Pays développés (MeSH)</term><term>Pays en voie de développement (MeSH)</term><term>Recherche comparative sur l'efficacité (méthodes)</term><term>Recherche comparative sur l'efficacité (tendances)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Comparative Effectiveness Research</term><term>Outcome Assessment, Health Care</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Recherche comparative sur l'efficacité</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Recherche comparative sur l'efficacité</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Comparative Effectiveness Research</term><term>Outcome Assessment, Health Care</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term><term>Delphi Technique</term><term>Developed Countries</term><term>Developing Countries</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Essais cliniques comme sujet</term><term>Humains</term><term>Méthode Delphi</term><term>Pays développés</term><term>Pays en voie de développement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Core outcome sets (COS) comprise a minimum set of outcomes that should be measured and reported in all trials for a specific health condition. The COMET (Core Outcome Measures in Effectiveness Trials) Initiative maintains an up to date, publicly accessible online database of published and ongoing COS. An annual systematic review update is an important part of this process.</p></sec><sec id="sec002"><title>Methods</title><p>This review employed the same, multifaceted approach that was used in the original review and the previous two updates. This approach has identified studies that sought to determine which outcomes/domains to measure in clinical trials of a specific condition. This update includes an analysis of the inclusion of participants from low and middle income countries (LMICs) as identified by the OECD, in these COS.</p></sec><sec id="sec003"><title>Results</title><p>Eighteen publications, relating to 15 new studies describing the development of 15 COS, were eligible for inclusion in the review. Results show an increase in the use of mixed methods, including Delphi surveys. Clinical experts remain the most common stakeholder group involved. Overall, only 16% of the 259 COS studies published up to the end of 2016 have included participants from LMICs.</p></sec><sec id="sec004"><title>Conclusion</title><p>This review highlights opportunities for greater public participation in COS development and the involvement of stakeholders from a wider range of geographical settings, in particular LMICs.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sox, Hc" uniqKey="Sox H">HC Sox</name></author><author><name sortKey="Greenfield, S" uniqKey="Greenfield S">S Greenfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williamson, Pr" uniqKey="Williamson P">PR Williamson</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author><author><name sortKey="Blazeby, Jm" uniqKey="Blazeby J">JM Blazeby</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name 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sortKey="Brookes, St" uniqKey="Brookes S">ST Brookes</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rosala Hallas, A" uniqKey="Rosala Hallas A">A Rosala-Hallas</name></author><author><name sortKey="Bhangu, A" uniqKey="Bhangu A">A Bhangu</name></author><author><name sortKey="Bowman, L" uniqKey="Bowman L">L Bowman</name></author><author><name sortKey="Blazeby, J" uniqKey="Blazeby J">J Blazeby</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Lang, T" uniqKey="Lang T">T Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirkham, Jj" uniqKey="Kirkham J">JJ Kirkham</name></author><author><name sortKey="Gorst, S" uniqKey="Gorst S">S Gorst</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author><author><name sortKey="Blazeby, J" uniqKey="Blazeby J">J Blazeby</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Devane, D" uniqKey="Devane D">D Devane</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Irlande (pays)</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Davis, Katherine" sort="Davis, Katherine" uniqKey="Davis K" first="Katherine" last="Davis">Katherine Davis</name></noRegion><name sortKey="Altman, Douglas G" sort="Altman, Douglas G" uniqKey="Altman D" first="Douglas G." last="Altman">Douglas G. Altman</name><name sortKey="Blazeby, Jane M" sort="Blazeby, Jane M" uniqKey="Blazeby J" first="Jane M." last="Blazeby">Jane M. Blazeby</name><name sortKey="Clarke, Mike" sort="Clarke, Mike" uniqKey="Clarke M" first="Mike" last="Clarke">Mike Clarke</name><name sortKey="Gargon, Elizabeth" sort="Gargon, Elizabeth" uniqKey="Gargon E" first="Elizabeth" last="Gargon">Elizabeth Gargon</name><name sortKey="Gorst, Sarah L" sort="Gorst, Sarah L" uniqKey="Gorst S" first="Sarah L." last="Gorst">Sarah L. Gorst</name><name sortKey="Harman, Nicola" sort="Harman, Nicola" uniqKey="Harman N" first="Nicola" last="Harman">Nicola Harman</name><name sortKey="Williamson, Paula R" sort="Williamson, Paula R" uniqKey="Williamson P" first="Paula R." last="Williamson">Paula R. Williamson</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Smith, Valerie" sort="Smith, Valerie" uniqKey="Smith V" first="Valerie" last="Smith">Valerie Smith</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Tunis, Sean" sort="Tunis, Sean" uniqKey="Tunis S" first="Sean" last="Tunis">Sean Tunis</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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